Choi et al, 2012: Atinaʻe Fluoride Neurotoxicity: O Se Faigofie Iloiloga ma Meta-Suʻesuʻega

lē faʻatino

Talaaga: E ui lava o le fluoride ono mafua ai le neurotoxicity i manu faʻataʻitaʻiga ma le oona fluoride oona mafua ai neurotoxicity i tagata matutua, laitiiti lava le iloa o ona aʻafiaga i tamaiti neurodevelopment.

Sini Autu: Na matou faia se iloiloga faʻasolosolo ma se faʻataʻitaʻiga o lomia faʻasalalau suʻesuʻega e suʻesuʻe ai i aʻafiaga o le faʻateleina o le fluoride ma faʻatuai ai le atinaʻeina o le neurobeh behavioral.

Metotia: Na matou suʻesuʻe i le MEDLINE, EMBASE, Water Resources Abstract, ma le TOXNET faʻamaumauga faʻasolosolo i le 2011 mo agavaʻa suʻesuʻega. Na matou suʻesuʻe foi i le nofoaga autu o Saina Atunuʻu Atinaʻe a le Atunuʻu (CNKI), ona o le tele o suʻesuʻega e uiga i le fluotide neurotoxicity ua faʻasalalau i mekasini a Saina. I le aotelega, na matou faʻailoaina 27 agavaʻa epidemiological suʻesuʻega ma maualuga ma faʻasino i faʻamatalaga, iʻuga o le IQ togi poʻo fesoʻotaʻiga gaioiga gaioiga gaioiga ma auala ma eseesega mo le lua faʻaaliga vaega. Na matou fuafuaina le faʻatusatusaina o uiga eseʻesega (SMD) i le va o le faʻaalia ma faʻasino vaega i luga o uma suʻesuʻega faʻaaogaina soʻoga aafiaga faʻataʻitaʻiga. Na matou faʻatautaia le faʻatatauina o auiliiliga faʻatapulaʻaina i suʻesuʻega faʻaaogaina le tutusa faʻatonuga faʻavasegaina ma le inuina o vai vai fluoride na o le pau le faʻaalia. Cochran suʻega mo le eseesega i le va o suʻesuʻega, Begg's funnel plot ma Egger suʻesuʻega e iloilo ai lolomiga faʻapitoa na faia. Meta-regressions e suʻesuʻe ai mafuaʻaga o fesuiaiga i uiga eseesega i totonu o suʻesuʻega na faia.

Iʻuga: O le faʻamamaina mamafa o lona uiga eseʻesega IQ togi i le va o le faʻaalia ma faʻasino faitau aofaʻi o -0.45 (95% CI -0.56 i le -0.35) faʻaaogaina se fua-faʻataʻitaʻi faʻataʻitaʻiga. O le mea lea, tamaiti i maualuga fluoride eria na maualalo maualalo togi IQ nai lo i latou oe nonofo i le maualalo vaega fluoride. Subgroup ma le maʻaleʻale suʻesuʻega na faʻailoa mai foʻi fegasoloaʻiga faʻafesoʻotaʻiga, e ui lava o le tele heterogeneity na foliga mai e le faʻaititia.

Faaiuga: O iʻuga e lagolagoina le ono iai o se faʻaletonu o le maualuga o le fluoride i luga o tamaiti. O suʻesuʻega i le lumanaʻi e tatau ona aofia ai faʻamatalaga auiliili o tulaga o tagata taʻitasi i luga o le prenatal exposure, neurobeh behavioral performance, ma covariates mo fetuunaiga.